Albuterol enantiomers : pre - clinical and clinical value ? Bill
نویسندگان
چکیده
1. Abstract 2. Introduction 3. The beta-agonist controversy in asthma 4. Effect of beta-2-adrenergic receptor agonists in animal and human model systems 4.1. Overview of preclinical data 4.2. Key preclinical enantiomer data on airway contractile function 4.2.1. In vitro animal models of airway contractility 4.2.2. In vivo animal models of airway contractility 4.2.3. Human airway tissue contractility 4.3. Key preclinical enantiomer data on airway inflammation effects 4.3.1. In vitro leukocyte models of inflammation 4.3.2. In vitro airway cell models of inflammation 4.3.3. In vivo animal studies of airway inflammation 5. Bronchoprovocation studies of enantiomers in asthmatics 6. Clinical effects potentially associated with (S)-albuterol 7. Effects of albuterol in clinical trials 7.1. Randomized controlled efficacy clinical trials of albuterol in asthma 7.2. Controlled trials in acute asthma in adults and children 8. Summary 9. Acknowledgements 10. References
منابع مشابه
Effects of albuterol enantiomers on ciliary beat frequency in ovine tracheal epithelial cells.
beta(2)-Adrenergic agonists stimulate ciliary beat frequency (CBF), an integral part of mucociliary clearance. To evaluate the differential effects of albuterol enantiomers and their racemic mixture on ciliary function, CBF and intracellular calcium were measured at room temperature from single ovine airway epithelial cells with use of digital videomicroscopy. Baseline CBF was 7.2 +/- 0.2 (SE) ...
متن کاملبررسی اثرات آلبوترول استنشاقی با دوز بالا(5/7 میلی‌گرم) در مقایسه با دوز پایین(5/2 میلی‌گرم) بر روی شاخص‌های تنفسی در بیماران مبتلا به بیماری انسدادی مزمن ریه با حمله حاد تنفسی
Background & Objective: Chronic obstructive pulmonary disease(COPD) is one of the most common causes of emergency department or hospital admissions in our country. COPD is a chronic progressive inflammatory disease that affects the elderly. Considering these facts, COPD is taken into account as a major cause of disability in developed and developing countries. The purpose of this study is t...
متن کاملAlbuterol enantiomer levels, lung function and QTc interval in patients with acute severe asthma and COPD in the emergency department
BACKGROUND This observational study was designed to investigate plasma levels of albuterol enantiomers among patients with acute severe asthma or COPD presenting to the emergency department, and the relationship with extra-pulmonary cardiac effects (QTc interval) and lung function. Recent reviews have raised concerns about the safety of using large doses of β2-agonists, especially in patients w...
متن کاملDevelopment and Validation of Bioanalytical Method for Simultaneous Estimation of Nebivolol Enantiomers in Human Plasma Using Liquid Chromatography-tandem Mass Spectrometry
The present study describes a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of S-RRR and R-SSS nebivolol (nebivolol enantiomers) in human plasma using solid phase extraction technique. Method of both S-RRR and R-SSS nebivolol (nebivolol enantiomers) has been developed and validated using racemic nebivolol D4 as an internal standard. Analytes...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2010